A total of 3,500 factory and office workers at Daimler, one of the world's biggest makers of heavy trucks, are to lose their jobs.
Daimler has said it will close two factories in Canada and the US, and drop its Sterling brand of trucks.
Daimler's truck sales in North America fell 18% in the first eight months of 2008 as economic growth slowed.
As well as 2,300 employees at the two factories, 1200 white-collar staff across the US and Canada will also go.
Daimler said it would switch some of its truck production to Mexico and other areas of the United States and hoped its truck customers would switch to its larger Freightliner brand.